The second release of the Great Power Arc.

An inevitable side-effect to the indomitable effectiveness of a certain wise-cracking webslinger has resulted in his enemies effectively unionizing! This evil expansion to Vs. System 2PCG includes an unprecidented SIX NEW MAIN CHARACTERS and presents a menacing collection of Spider-Man's most notorious villains!

Vs. System 2PCG: Sinister Syndicate showcases 55 new cards that showcase Spider-Man's greatest foes. Including Main Characters, Supporting Characters, Plot Twists, and a Special Location. Vs System 2PCG: Sinister Syndicate can be combined with any other Vs System 2PCG sets.